Lindsay Kyed

  • Lindsay Kyed posted an update 1 day, 8 hours ago

    The meta-analysis is a powerful statistical tool to estimate the incidence and risk of those uncommon serious drug-related toxicities and this approach has been utilized to demonstrate an increased risk in treatment related mortality with bevacizumab and VEGFR-TKIs in previous researches. To the best of our knowledge, this is the first…[Read more]

  • Additionally, our study includes a mixed population of patients treated mTOR inhibitors-based combination therapy or mTOR inhibitors alone, and patients received placebo or non-placebo therapy were also included in our study. Therefore, the treatment design is not the same in all arms, and it might be another source of heterogeneity. Finally, it…[Read more]

  • The meta-Compound C108 analysis is a powerful statistical tool to estimate the incidence and risk of those uncommon serious drug-related toxicities and this approach has been utilized to demonstrate an increased risk in treatment related mortality with bevacizumab and VEGFR-TKIs in previous researches. To the best of our knowledge, this is the…[Read more]

  • Additionally, our study includes a mixed population of patients treated mTOR inhibitors-based combination therapy or mTOR inhibitors alone, and patients received placebo or non-placebo therapy were also included in our study. Therefore, the treatment design is not the same in all arms, and it might be another source of heterogeneity. Finally, it…[Read more]

  • Lindsay Kyed posted an update 1 week ago

    Moreover, the new definition of drug resistant epilepsy was failure of adequate trials of two tolerated and appropriately chosen and used AED schedules to achieve sustained seizure freedom. In all eligible studies, types of AEDs were also variable. Moreover, drug-response was defined as patients with no seizure for more than three times the…[Read more]

  • Lindsay Kyed posted an update 1 week, 1 day ago

    Additionally, our study includes a mixed population of patients treated mTOR inhibitors-based combination therapy or mTOR inhibitors alone, and patients received placebo or non-placebo therapy were also included in our study. Therefore, the treatment design is not the same in all arms, and it might be another source of heterogeneity. Finally, it…[Read more]

  • Lindsay Kyed posted an update 1 week, 1 day ago

    Meanwhile, the potent anti-platelet activity of K-134 also make it a potential alternative agent for preventing secondary cerebral infarction because antiplatelet therapy for secondary stroke prevention has been proved to be beneficial in clinical trials. Moreover, a double-blind, randomized trial of cilostazol and aspirin demonstrated that…[Read more]

  • Lindsay Kyed posted an update 1 week, 2 days ago

    Moreover, the new definition of drug resistant epilepsy was failure of adequate trials of two tolerated and appropriately chosen and used AED schedules to achieve sustained seizure freedom. In all eligible studies, types of AEDs were also variable. Moreover, drug-response was defined as patients with no seizure for more than three times the…[Read more]

  • Lindsay Kyed posted an update 1 week, 2 days ago

    The meta-analysis is a powerful statistical tool to estimate the incidence and risk of those uncommon serious drug-related toxicities and this approach has been utilized to demonstrate an increased risk in treatment related mortality with bevacizumab and VEGFR-TKIs in previous researches. To the best of our knowledge, this is the first…[Read more]

  • Lindsay Kyed posted an update 2 weeks ago

    Studies on the pathogenic mechanisms of RA have revealed that tumor necrosis factor is a cytokine playing a critical role in the inflammatory TC ASK 10 cascade that results in the irreversible joint damage typical of the disease. Following these discoveries, a series of clinical trials in patients with RA showed the therapeutic benefit of TNF…[Read more]

  • Lindsay Kyed posted an update 2 weeks, 1 day ago

    Diverse roles in disease development and progression have led MMPs to be regarded as promising therapeutic targets, resulting in development of many small-molecule MMP inhibitors, but clinical trials of early-generation MMP inhibitors in cancer and arthritis proved disappointing. Broad-spectrum MMP inhibitors produced serious dose-limiting…[Read more]

  • Genome-wide resource reallocation is perhaps an accommodation essential for insect survival. Among bergapteninduced genes are P450, GST, CAT and LAC2 genes, known to encode allelochemical-detoxifying enzymes that confer metabolic resistance, or phenoloxidase that possibly increases resistance to penetration of bergapten. Thus it is a logical…[Read more]

  • Diverse roles in disease development and progression have led MMPs to be regarded as RuBi-4AP promising therapeutic targets, resulting in development of many small-molecule MMP inhibitors, but clinical trials of early-generation MMP inhibitors in cancer and arthritis proved disappointing. Broad-spectrum MMP inhibitors produced serious…[Read more]

  • Diverse roles in disease development and progression have led MMPs to be regarded as promising therapeutic targets, resulting in development of many small-molecule MMP inhibitors, but clinical trials of early-generation MMP inhibitors in cancer and arthritis proved disappointing. Broad-spectrum MMP inhibitors produced serious dose-limiting…[Read more]

  • Lindsay Kyed posted an update 4 weeks, 1 day ago

    The novel epitopes could provide a protective effect and thus lower viral levels, delaying the progression of HIV infection to AIDS. Even though only two overlapping potential epitopes are presented here, it is believed to be significant in supporting an argument that HLA allotype should be taken into consideration when patients start HIV…[Read more]

  • Lindsay Kyed posted an update 1 month ago

    Thus, although neutrophils are the cells that increase in the bronchoalveolar lavage after ozone, it is tissue eosinophils around airway nerves that mediate ozone-induced hyperreactivity. In eosinophils, eotaxin and IL-5 signal through both ERK and p38 MAPK activation. Inhibition of p38 reduces eosinophil degranulation as measured by decreased…[Read more]

  • Lindsay Kyed posted an update 1 month ago

    Thus, although neutrophils are the cells that increase in the bronchoalveolar lavage after ozone, it is tissue eosinophils around airway nerves that mediate ozone-induced hyperreactivity. In eosinophils, eotaxin and IL-5 signal through both ERK and p38 MAPK activation. Inhibition of p38 reduces eosinophil degranulation as measured by decreased…[Read more]

  • The novel epitopes could provide a protective effect and thus lower viral levels, delaying the progression of HIV infection to AIDS. Even though only two overlapping potential epitopes are presented here, it is believed to be significant in supporting an argument that HLA allotype should be taken into consideration when patients start HIV…[Read more]

  • The novel epitopes could provide a protective effect and thus lower viral levels, delaying the progression of HIV infection to AIDS. Even though only two overlapping potential epitopes are presented here, it is believed to be significant in supporting an argument that HLA allotype should be taken into consideration when patients start HIV…[Read more]

  • The novel epitopes could provide a protective effect and thus lower viral levels, delaying the progression of HIV infection to AIDS. Even though only two overlapping potential epitopes are presented here, it is believed to be significant in supporting an argument that HLA allotype should be taken into consideration when patients start HIV…[Read more]

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