Bessie Parks

  • The possibility that population admixture has distorted the strength of the pooled estimate of association remains. Family-based studies using transmission disequilibrium testing to account for population admixture have not yet examined the association of the PAI-1 polymorphism with pre-eclampsia. A major limiting factor in determining the…[Read more]

  • While the levels of PrPC were increased, it is unclear if the increase is significant enough to be biologically relevant as the magnitude of change was small. Similarly, there was no evidence of PRNP expression inhibition in Rov9 cells as the direction of changes in PRNP transcript levels in Rov9 cells was towards an increase in PRNP transcript…[Read more]

  • We have previously demonstrated associations between- and negative predictive values of high circulating catecholamines and endothelial damage in trauma, sepsis and ST segment elevation myocardial infarction patients. However, no studies have previously investigated the association between circulating catecholamines, endothelial damage and outcome…[Read more]

  • Bessie Parks posted an update 1 week, 2 days ago

    While the levels of PrPC were increased, it is unclear if the increase is significant enough to be biologically relevant as the magnitude of change was small. Similarly, there was no evidence of PRNP expression inhibition in Rov9 cells as the direction of changes in PRNP transcript levels in Rov9 cells was towards an increase in PRNP transcript…[Read more]

  • Bessie Parks posted an update 1 week, 3 days ago

    The possibility that population admixture has distorted the strength of the pooled estimate of association remains. Family-based studies using transmission disequilibrium testing to account for population admixture have not yet examined the association of the PAI-1 polymorphism with pre-eclampsia. A major limiting factor in determining the…[Read more]

  • Bessie Parks posted an update 1 week, 3 days ago

    While the levels of PrPC were increased, it is unclear if the increase is significant enough to be biologically relevant as the magnitude of change was small. Similarly, there was no evidence of PRNP expression inhibition in Rov9 cells as the direction of changes in PRNP transcript levels in Rov9 cells was towards an increase in PRNP transcript…[Read more]

  • Bessie Parks posted an update 1 week, 4 days ago

    We have previously demonstrated associations between- and negative predictive values of high circulating catecholamines and endothelial damage in trauma, sepsis and ST segment elevation myocardial infarction patients. However, no studies have previously investigated the association between circulating catecholamines, endothelial damage and outcome…[Read more]

  • Bessie Parks posted an update 1 week, 5 days ago

    Recently, Hagihara et al reported in a prospective observational propensity score analysis of data from 417,188 OHCA patients that use of prehospital adrenaline was associated with increased chance of ROSC before hospital arrival but also with decreased chance of survival and good functional outcomes 1 month after the event. This is in accordance…[Read more]

  • Bessie Parks posted an update 1 week, 5 days ago

    While the levels of PrPC were increased, it is unclear if the increase is significant enough to be biologically relevant as the magnitude of change was small. Similarly, there was no evidence of PRNP expression inhibition in Rov9 cells as the direction of changes in PRNP transcript levels in Rov9 cells was towards an increase in PRNP transcript…[Read more]

  • Bessie Parks posted an update 1 week, 6 days ago

    While the levels of PrPC were increased, it is unclear if the increase is significant enough to be biologically relevant as the magnitude of change was small. Similarly, there was no evidence of PRNP expression inhibition in Rov9 cells as the direction of changes in PRNP transcript levels in Rov9 cells was towards an increase in PRNP transcript…[Read more]

  • Similar RU 28318, potassium salt results were observed in parental CMS4 cells in response to the different treatments, indicating that the lack of TSAinduced STAT1 phosphorylation did not reflect subline-specific differences. These results indicate that the ability of TSA to enhance IRF-8 promoter activity is STAT1-dependent ; albeit, it does not…[Read more]

  • To evaluate dietary bergapten impact on fecundity, cowpea bruchids reared on artificial seeds containing 250 ppm bergapten were produced as above. Newly emerged adults from these seeds, four female and two male, were placed in a separate bottle and eggs laid were recorded and removed daily till all insects died. Three replicates were performed.…[Read more]

  • Current reports highlight the cell type specific differences in response to pharmaceutical intervention at the level of F508delCFTR processing. Furthermore the response to correctors varies considerably between cell pools from different donors. Previously, variations of clinical phenotype in patients homozygous for F508del, were shown to correlate…[Read more]

  • Current reports highlight the cell type specific differences in response to pharmaceutical intervention at the level of F508delCFTR processing. Furthermore the response to correctors varies considerably between cell pools from different donors. Previously, variations of clinical phenotype in patients homozygous for F508del, were shown to correlate…[Read more]

  • To evaluate dietary bergapten impact on fecundity, cowpea bruchids reared on artificial seeds containing 250 ppm bergapten were produced as above. Newly emerged adults from these seeds, four female and two male, were placed in a separate bottle and eggs laid were recorded and removed daily till all insects died. Three replicates were performed.…[Read more]

  • Current reports highlight the cell type specific differences in response to pharmaceutical intervention at the level of F508delCFTR processing. Furthermore the response to correctors varies considerably between cell pools from different donors. Previously, variations of clinical phenotype in patients homozygous for F508del, were shown to correlate…[Read more]

  • Similar results were observed in parental CMS4 cells in response to the different treatments, indicating that the lack of TSAinduced STAT1 phosphorylation did not reflect subline-specific differences. These results indicate that the ability of TSA to enhance IRF-8 promoter activity is STAT1-dependent ; albeit, it does not coincide with STAT1…[Read more]

  • Bessie Parks posted an update 4 weeks ago

    Last, SUGAR-MGH could be employed to identify genetic variants that differentially influence the responses to the two pharmacological challenges. Given the different time scales of the interventions, this approach would require that a chosen glipizide phenotype be normalized across all participants and compared against a similarly normalized…[Read more]

  • It is known that some substrates, including other tyrosine kinase inhibitors, stimulate ATPase activity of ABCB1 and ABCG2 at lower concentrations, but inhibit ATPase activity at higher concentrations. Taken together, the data in Figure 2 suggest that quizartinib may be transported by both ABCB1 and ABCG2 at lower concentrations. However, this…[Read more]

  • It is known that some substrates, including other tyrosine kinase inhibitors, stimulate ATPase activity of ABCB1 and ABCG2 at lower concentrations, but inhibit ATPase activity at higher concentrations. Taken together, the data in Figure 2 suggest that quizartinib may be transported by both ABCB1 and ABCG2 at lower concentrations. However, this…[Read more]

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